Creative Proteomics is a leading biotechnology company committed to advancing peptidomics research. We offer innovative solutions to unravel the complexity of post-translational modifications (PTMs) in peptides, helping customers better understand cellular processes and disease mechanisms， and develop novel therapeutics. Our dedication to scientific excellence, cutting-edge technology, and customer satisfaction has made us a trusted partner for researchers and institutions worldwide.
What are Peptide PTMs?
Peptide PTMs refer to the chemical modifications that occur on proteins after their synthesis (translation) from messenger RNA (mRNA). These modifications play a crucial role in regulating protein structure, function, localization, stability, and interactions with other molecules. Each modification imparts unique properties to the protein, expanding its functional repertoire and influencing cellular processes.
Our Peptide PTMs Identification Process
At Creative Proteomics, our peptide PTMs identification process combines cutting-edge technologies and expert analysis to deliver accurate and reliable results.
Consultation and Sample Submission
Researchers and institutions can consult with our experts to discuss their specific needs and objectives. Upon agreement, samples are submitted for analysis, accompanied by relevant information about the peptide of interest and any known modifications.
Sample Preparation
Our skilled scientists employ optimized protocols to extract peptides and digest them. Special care is taken to preserve the integrity of PTMs during the sample preparation process.
MS Analysis
MS is a powerful technique used to analyze peptides and identify PTMs. We utilize advanced mass spectrometry platforms capable of high-resolution and high-throughput analysis.
Data Interpretation
The obtained MS data is subjected to rigorous bioinformatics analysis using cutting-edge algorithms and software. Our experts employ comprehensive database searches, statistical analysis, and data visualization to identify and interpret PTMs.
Report Delivery
Once the identification process is complete, we generate a detailed report summarizing the findings. The report includes information on the identified modifications, their locations within the peptide sequence, and any additional insights gained from the analysis. The report is delivered to the client for further exploration and interpretation.
Applications of Our Peptide PTMs Identification Services
The identification of peptide PTMs has wide-ranging applications across various fields of research and industry.
Understanding Cellular Signaling
PTMs control intracellular signaling pathways. We help clients gain a deeper understanding of cellular communication and signaling and develop targeted therapies.
Disease Mechanism Investigation
By identifying and characterizing disease relevant PTMs, we help clients understand disease mechanisms and develop new therapeutic interventions.
Protein Engineering and Biotechnology
PTMs are key determinants of peptide structure, stability, and function. By understanding and manipulating these modifications, we can engineer proteins with enhanced properties for industrial and therapeutic applications.
Plant Growth and Development Research
PTM peptides (PMPs) play an important role in plant growth and development. We can help botanists study the mechanism of action of signaling peptides.
Advantages of Our Peptide PTMs Identification Services
The mass spectrometers and chromatographs we use have high resolution and sensitivity.
Our services cover a variety of polypeptide PTM types, including phosphorylation, glycosylation, methylation, acetylation, and ubiquitination, and can meet the needs of customers in different fields.
We provide personalized service solutions based on customer needs.
We adhere to strict protocols to protect sensitive information, ensuring that research data and results remain confidential and are handled with the utmost care.
At Creative Proteomics, we offer cutting-edge peptide PTM identification services, empowering researchers to unlock the secrets of peptide modifications and advance their understanding of biology and disease. Our comprehensive identification process, supported by advanced mass spectrometry and bioinformatics analysis, delivers reliable results with high accuracy and sensitivity. Our team of experts is ready to assist you in your research endeavors and provide tailored solutions to meet your specific needs!
References
- Kacen A.; et al. Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors. Nat Biotechnol. 2023, 41(2):239-251.
- Stintzi A.; et al. Biogenesis of post-translationally modified peptide signals for plant reproductive development. Curr Opin Plant Biol. 2022, 69:102274.
* For research use only. Not for use in diagnostic procedures!
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