In Vivo Drug Pharmacokinetic Assays
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In vivo pharmacokinetic testing is a crucial step in the development and evaluation of antibody drugs. This testing involves the study of how the drug is absorbed, distributed, metabolized, and eliminated within a living organism, typically through the use of animal models. At Creative Proteomics, a leading drug research service provider, we specialize in providing comprehensive in vivo pharmacokinetic testing services for antibody drugs. Our services range from biodistribution studies to clearance studies and pharmacokinetic modeling, and are critical for determining complex details of a drug such as half-life, bioavailability and distribution in various organs and tissues.
Introduction of In Vitro Metabolism Assay Services for Antibody Drugs
Our in vivo pharmacokinetic testing services cover a wide range of parameters to ensure a thorough evaluation of antibody drug candidates. These include:
- Absorption studies: We investigate how antibodies are absorbed after administration, be it via intravenous, intramuscular, subcutaneous, or oral routes. This data is essential for determining the optimum dosing method.
- Distribution studies: Understanding the distribution of antibody drugs within the body is critical. We conduct studies to evaluate tissue and organ-specific distribution, plasma protein binding, and penetration into specific physiological compartments.
- Metabolism studies: Antibodies can undergo various metabolic processes that may impact their efficacy and safety. We analyze drug metabolism, including identification of potential metabolites, assessment of enzyme-mediated metabolism, and identification of metabolic pathways.
- Elimination studies: Determining the clearance rate and elimination pathways of antibody drugs is vital for estimating their half-life and dosing frequency. Our testing services include the evaluation of renal clearance, hepatic clearance, and other routes of elimination.
Our Testing Capability of Antibody Drugs In Vitro Metabolism Assay
We provide a wide range of animal models suitable for studying in vivo pharmacokinetics of antibody drugs, including mice, rats, rabbits, and non-human primates. These models enable us to assess drug behavior in vivo with relevance to human physiology.
Our expertise covers a variety of administration routes for antibody drugs, such as intravenous (IV), subcutaneous (SC), intramuscular (IM), and intraperitoneal (IP) administrations. We have the necessary infrastructure and experience to execute these routes efficiently.
Our capabilities involve the collection and analysis of various biological samples necessary for pharmacokinetic studies, including blood, plasma, serum, urine, and tissues. These samples enable us to quantify drug concentrations, evaluate drug distribution, and assess metabolic processes.
We can assess drug distribution and elimination by targeting specific organs of interest. This includes sampling from organs such as the liver, kidneys, lungs, spleen, heart, and brain, among others. By analyzing drug concentrations in these organs, we gain valuable insights into drug localization and potential organ-specific effects.
Our assays include the assessment of drug excretion and elimination pathways. We can measure drug concentrations in urine and feces to determine renal and fecal clearance, respectively. This helps in understanding the contribution of different excretory routes to overall drug elimination.
We employ a range of experimental methods to conduct our pharmacokinetic assays. These involve techniques such as liquid chromatography-mass spectrometry (LC-MS), enzyme-linked immunosorbent assays (ELISA), and radioimmunoassays (RIA).
Services Features of Our In Vitro Metabolism Assay Services
- Accurate measurement of drug concentration.
- Multiple species availability.
- Customizable study design.
- High-throughput capability.
- Comprehensive data analysis.
- Regulatory compliance.
Creative Proteomics' team consists of experienced scientists who work closely with clients to design in vivo pharmacokinetic assays for antibody drugs. Our extensive capabilities in all aspects of these assays ensure accurate and reliable assessment of drug properties to accelerate their development. For more information or to request our services, please feel free to contact us.
