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Biomolecular Interaction Analysis

Surface Plasmon Resonance, SPR for short, is defined as the excitation of surface plasmon (collective charge oscillation along the interface between two materials) by incident light under the condition of total internal reflection. During SPR, the surface electrons of the interface resonate at the same frequency as the light. But the adsorption of biomolecules onto the interface would change oscillation frequency of surface electrons. Several SPR-based biosensors, such as auto-lab, Biacore and ProteOn XPR36 have been developed for application in biochemical researches, and the most popular technique based on SPR, is Biacore for accurate characterization of biomolecular interaction.

Currently the Biacore technique, an optical-based detection system, is considered as an ideal tool to explore biomolecules interactions of various pairs of partners. When the the analytes in the solution passing through bind with the immobilized ligands on the surface, Biacore can detect the changes of reflection angle close to the metal surface. Immobilizing different ligands on various sensor surface (the most popular one is CM5), allows the monitoring of the following biomolecular interactions:

Protein-Protein Interaction

Nucleic Acid-Protein Interaction

Protein-Small Molecule Interaction

With the Biacore technique, Creative Proteomics can perform real-time monitoring of the binding/dissociation of analytes & corresponding ligands, which provides rapid stoichiometric kinetic, affinity and thermodynamic measurement. The advantages above, make Biacore popular in:

Immunologic Test & Biochemical Research

Drug Discovery & Screening

Nucleic Acid-Nucleic Acid & Nucleic Acid-Protein Interaction

Proteomics Research

With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions.

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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