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Endocrine Disruptors Analysis Service

Endocrine disruptors are chemicals that interfere with the body's endocrine system and produce adverse neurological, developmental, reproductive, and immunological effects in humans and animals. Endocrine disruptors can affect every level of the endocrine system and have the ability to bind and activate endocrine receptors (ERs) in the target tissue. Based on the effects of endocrine disruptors, some scientists classify endocrine disruptors into three classes: obesity related, hormone disrupting, and cancer related.

Figure1. Common molecular mechanisms of endocrine disruptors. (Yang O, et al, 2015.)

Endocrine disruptors can be found in many products, including plastic bottles, flame retardants, metal food cans, detergents, food, toys, pesticides, and cosmetics. Due to the toxicity of endocrine disruptors, we should monitor them in the environment or in the products. Therefore, many possible endocrine disruptors are technically regulated in the United States.

Endocrine Disruptors Analysis at Creative Proteomics

At Creative Proteomics, we can use various analytical methods for endocrine disrupter analysis. And we can accurate analysis not only what endocrine disrupting compounds are present in these samples, but how much are there. Creative Proteomics can analyze many endocrine disrupting compounds, including but not limited:

Bisphenol-A
Mono-(2-ethyl-5-hydroxyhexyl) phthalate
Mono-(2-ethyl-5-oxohexyl) phthalate
Mono-ethylhexyl phthalate
Mono-n-butyl phthalate

At Creative Proteomics, we have sophisticated instruments and professional technicians to provide excellent identification and quantitative analytical information for endocrine disrupting. There are various analytical methods to be widely used to determine various kinds of trace level organic compounds of endocrine disrupting, including but not limited:

Extraction methods: solid phase extraction (SPE), solid phase microextraction (SPME), and liquid phase microextraction (LPME), etc.
Mass-based analytical methods: gas chromatography-mass spectrometry (GC-MS), liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), chromatography-tandem mass spectrometry (GC–MS/MS), high performance liquid chromatography (HPLC), high performance liquid chromatography with positive electrospray ionization and tandem mass spectrometry (HPLC/ESI-MS/MS), etc.

Our Advantages

Very low levels of endocrine disruptor compounds can be detected.
Provide enough sensitivity to analyze endocrine disruptor compounds with minimum sample preparation.
We can analyze endocrine disruptor in complex matrices, such as water, soil, foods, or other products, etc.

Creative Proteomics is a leading biotech company specializing in offering a set of services for endocrine disrupting analysis. Depending on the target compounds, various combinations of instruments and detectors can be applied to obtain improved analytical results. Our high-quality data and efficiency of the experimental cycle meet the demands for environment analysis solution, acquiring the customer's consistent good comments. If you have any questions or specific requirements, please do not hesitate to contact us.

References

Yang O, et al. Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis. Journal of cancer prevention. 2015, 20(1):12-23.
Chang H S, et al. The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water. Journal of Hazardous Materials. 2009, 172: 1–12.

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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