Creative Proteomics delivers comprehensive Gas Chromatography-Mass Spectrometry (GC-MS) analysis services, a pivotal resource across industries such as pharmaceuticals, food safety, environmental monitoring, forensic science, and biomedical research. With considerable expertise in the precise identification and quantification of metabolites, lipids, and glycans, the team at Creative Proteomics applies cutting-edge technology to support customized experimental design and thorough data interpretation. Clients benefit from reliable, accurate results with swift turnaround times and competitively structured pricing, providing dependable and comprehensive analytical solutions tailored to meet diverse research and industry needs.
What is GC-MS Analysis?
GC-MS is a highly versatile analytical technique that integrates the separation power of gas chromatography with the molecular identification and quantification capabilities of mass spectrometry, proving indispensable across numerous industries. In pharmaceuticals, GC-MS is critical for ensuring product safety and regulatory compliance through precise analysis of active ingredients and contaminants. Within the food and beverage sector, it serves to detect harmful substances and verify product authenticity. Environmental scientists deploy GC-MS to monitor pollutants, while forensic experts depend on its accuracy for identifying substances in criminal investigations. Research institutions apply GC-MS for detailed compositional analyses, and clinical laboratories utilize it to analyze biological samples, deepening insights into drug metabolism and disease mechanisms. In sum, GC-MS is foundational for advancing safety, compliance, and innovation across pharmaceuticals, food safety, environmental monitoring, forensic science, and biomedical research.
Why You Might Need GC-MS?
Have you encountered challenges in detecting trace amounts of chemicals in your samples?
GC-MS analysis could be the solution you need. Its high sensitivity allows for the detection of chemical species at extremely low concentrations, often down to parts per billion.
Are you struggling to analyze complex mixtures in food, pharmaceuticals, or industrial products?
GC-MS excels in separating and identifying individual components within these mixtures, providing a comprehensive analysis of sample composition that can help you make informed decisions.
Maybe you're worried about verifying the quality of your raw materials and finished products?
GC-MS can help verify the composition of both raw materials and finished products, ensuring they meet established quality standards and helping you maintain customer trust.
Common Applications of GC-MS
- Environmental Analysis: Monitoring pollutants in air, soil, and water samples to assess environmental health and safety.
- Food and Beverage Testing: Detecting contaminants, residues, and flavoring compounds to ensure food safety and quality.
- Pharmaceutical Analysis: Identifying active pharmaceutical ingredients and detecting residual solvents in drug formulations.
- Forensic Science: Analyzing substances in crime scene investigations, including drugs and toxins.
- Chemical Research: Supporting research in various fields, including organic chemistry and material science, by providing detailed compositional analysis.
- Biological Research: Analyzing small molecules in biological samples,to reveal drug metabolism processes and their effects on organisms.
Scope of GC-MS in Bioanalysis
In the field of bioanalysis, GC-MS plays a crucial role in drug testing, biomarker discovery, and the study of metabolites. Its high sensitivity and specificity make it ideal for:
Metabolomics: Profiling small molecules in biological samples to understand metabolic pathways and disease mechanisms.
Pharmacokinetics: Studying the absorption, distribution, metabolism, and excretion of drugs by quantifying drug levels in biological fluids.
Toxicology: Identifying toxic substances in biological samples, aiding in the assessment of exposure risks and safety evaluations.
What Our GC-MS Analysis Service Offer
At Creative Proteomics, our GC-MS Analysis Service encompasses all stages, including sample preparation, analysis, and data processing. Leveraging advanced technology and a team of experienced experts, we provide professional support for clients' experimental design and data interpretation. Below are some commonly analyzed substances via GC-MS; for other needs, you can click this targeted metabolomics link, or contact us. We have the capability to detect a wide range of compounds, with applications extending across metabolomics, lipidomics, and glycomics.
How Does GC-MS Work?
The GC-MS process involves several key processes,samples are first prepared and vaporized in the heated inlet of the gas chromatograph. The vaporized sample is then carried through the GC column by an inert gas, where different compounds are separated based on their chemical properties. As the compounds exit the GC, they are ionized in the mass spectrometer, typically using electron ionization (EI), creating charged fragments. These ionized fragments are then analyzed based on their mass-to-charge ratio (m/z), resulting in a mass spectrum that is used for identification and quantification.
(Li, D. X et.al., Analytica chimica acta 2015)
Sample Extraction Methods of GC-MS
- Solvent Extraction: Uses organic solvents like hexane, dichloromethane, and acetone to extract analytes from the sample matrix.
- HS-SPME: Isolates volatile organic compounds from the headspace above a sample, reducing matrix interference.
- Derivatization: Involves chemically modifying certain compounds to enhance volatility and detection sensitivity before injection.
Why Choose Our GC-MS Analysis Service
Fast Turnaround Times
Personalized Service
Competitive Pricing
Result Accuracy Guarantee
Professional Team and Advanced Equipment
Custom Tailored Expert Guidance
FAQs
What is an advantage of GC-MS?
A key advantage of Gas Chromatography-Mass Spectrometry (GC-MS) is its ability to provide both qualitative and quantitative analysis of complex mixtures. It accurately identifies compounds based on their mass-to-charge ratios (m/z) and retention times, allowing for the detection of a wide range of substances, even in challenging samples.
What is the difference between GC-MS and LC-MS?
GC-MS and LC-MS are both analytical techniques designed to separate, identify, and quantify compounds within complex mixtures, yet they utilize different approaches to achieve these goals. The primary distinction lies in their mobile phases: GC-MS employs a gas mobile phase along with heat to transport and separate samples, whereas LC-MS utilizes a liquid mobile phase combined with ionization for separation. Despite this fundamental difference, the two methods share more similarities than differences, both effectively serving in analytical applications across various fields.
How are target compounds identified and quantified in GC-MS data processing?
The identification of target compounds primarily relies on comparing these mass spectra to known databases (mass spectral libraries) and correlating retention times against standards. For quantification, calibration standards are analyzed to create a curve that correlates peak areas to concentrations, with integration used to calculate the amount of each target compound based on its peak area.
What is the limitations of GC-MS ?
GC-MS, while powerful for analyzing volatile and semi-volatile compounds, faces challenges with non-volatile substances, often requiring derivatization or alternative methods. Additionally, GC-MS can be sensitive to matrix effects, affecting data accuracy, and has limited capability in detecting certain atmospheric gases like CO₂ and N₂, which may need specialized techniques. LC-MS can complement GC-MS in these areas, offering enhanced suitability for non-volatile and thermally labile compounds, thereby expanding analytical scope.
