KEGG Enrichment Analysis

KEGG Enrichment Analysis

Introduction of KEGG

KEGG (Kyoto Encyclopedia of Genes and Genomes) database is an important bioinformatics data set, which is the integration and interpretation of large-scale molecular datasets generated by genome sequencing and other high-throughput experimental techniques. A variety of genomic, chemical and system functional information have been integrated into the KEGG database, in which biological metabolic pathways are classified into 6 categories, namely, cellular processes, environmental information processing, genetic information processing, human diseases, metabolism, and organismal systems. Aiming to carry on annotations and metabolic pathway analyses of differential expressed metabolites, Creative Proteomics has introduced multiple analysis software packages to perform KEGG enrichment analysis.

Application of KEGG pathway enrichment analysis in biology

• Prediction of protein interaction networks of various cellular processes
• Integration of current knowledge about molecular interaction networks, such as pathways and complexes, as well as information about gene and protein generated by genomic projects
• Functional annotation of differentially expressed genes to understand the related functions and pathways of differentially expressed genes
• Transcriptome, methylation, ChIP-seq, microbiome, resequencing and other data analysis

Figure 1. KEGG annotations and enrichment of differentially expressed metabolites. (Meng, Y.; et al. 2019)

Our Services

Creative Proteomics has developed a novel metabolic flux analysis platform to provide KEGG enrichment analysis service in a competitive fashion. We can offer a wide range of services to support all research and development activities.

• We conduct KEGG annotations and metabolic pathway analyses of differential expressed metabolites
• For metabolites in each module, KEGG pathway enrichment analysis is carried out to analyze their biological functions
• Significantly enriched pathways in which the metabolites in a module involved are compared to the background and defined by both a hypergeometric test and a threshold of P < 0.05

Advantages of Our Services

• Creative Proteomics supports various cutting-edge display methods such as bubble plots and histograms for KEGG enrichment analysis
• Our high-quality KEGG pathway analysis graphing service allows you to quickly obtain accurate results and visual graphs
• Various analysis tools or software packages are available for KEGG pathway enrichment analysis
• Our team can also offer a customized KEGG pathway analysis services based on your needs, including specific analysis software or charting requirements
• Various formats of data for analysis are available, and the input data can be genomic, transcriptomic, methylation, microbiome, ChIP-seq, and various microarray data

Features of Our MFA Platform

• Developed based on the most updated knowledge of biology, bioinformatics and software development
• Widely applicable to a wide range of metabolic system
• Professional bioinformatics teams & personalized bioinformatics analysis services.
• Advanced instrument platform
• Integrated quantitative methodologies and comprehensive solutions for metabolomics

Based on high-performance quantitative techniques and advanced equipment, Creative Proteomics has constantly updating our metabolic flux analysis platform and is committed to offering professional, rapid and high-quality services of KEGG enrichment analysis at competitive prices for global customers. Our personalized and comprehensive services can satisfy any innovative scientific study demands, please contact our specialists to discuss your specific needs. We are looking forward to cooperating with you!

Reference

1. Meng, Y.; et al. Metabolic profile analysis and identification of key metabolites during rice seed germination under low-temperature stress - ScienceDirect. Plant Science. 2019. 289: 110282-110282.