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Lactylation Analysis Service

The discovery of lactylation modifications in 2019 has led to new directions for the study of the metabolite lactate's involvement in oncology, immunity, and other fields. Creative Proteomics offers high-quality acylation analysis services, including identification, quantification and characterization, providing valuable insights into your protein research.

What is Lactylation

In 2019, it was found that lactic acid accumulated during metabolism can act as a precursor substance leading to lactate modification of histone lysine and participate in the homeostatic regulation of bacterial-infected M1 macrophages, modulating inflammation, cancer, and other diseases. This broadens the way for the study of lactonization of proteins. Lactonization is one of the important post-translational modifications of proteins and may occur on any protein residue with a free amino group, such as lysine, arginine and tyrosine. In the presence of lactonase (lactoyl-CoA transferase), lactic acid is ester-bonded to the amino acid residues of the substrate protein, lactonizing it.

Fig.1 Schematic of Acetylation

Fig.1 Schematic of lactylation (Hagihara, H. et al., 2021)

As a type of post-translational modification of proteins, some studies have confirmed that lactylation modification is an important way for lactic acid to exert its function, which is involved in glycolysis-related cellular functions, macrophage polarization, vascular function, mitochondria, nervous system regulation and other important life activities, and can guide new directions for research in the fields of tumors, immunity and so on.

Applications of Lactylation Analysis

The study of lactylation has a wide range of applications, including but not limited to the understanding of protein structure and function, the study of disease pathogenesis, and the development of novel drugs, and also contributes to our understanding of the complexity and dynamics of biological systems.

Our Service

Creative Proteomics has advanced protein detection technologies and can provide customized services to researchers and scientists to help them reveal the complexity of PTM using powerful mass spectrometry technologies. Our services are thoughtful and detailed and the process of lactylation analysis service is as follows:

Fig.2 Lactylation analysis workflow

Fig.2 Lactylation analysis workflow

Creative Proteomics brings a wealth of experience to the field of protein research. Our comprehensive services and products cover the entire spectrum of utilizing suitable and efficient gateways. Utilizing our proprietary platform, we have successfully implemented many proteomics research projects. If you are interested, please contact us for more information and a quote.

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