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Protein Interaction Analysis Service

As the main carrier of life's activities, protein influences almost all biological systems, while it usually does not work alone. Most of proteins interact with other substances to carry out life processes, such as DNA, RNA, metabolites, and other proteins. Therefore, it is essential for protein research to analyze protein interactions. Creative Proteomics provides comprehensive and detailed protein interaction analysis services with years of experience in proteomics research.

What is Protein Interaction

To be effective, proteins usually require the interaction with other molecules. It is almost present in all biological processes, such as transcription, translation, substance transport, signaling, biochemical reactions, etc. As a result, it plays a crucial role in medical, biological, and other research. Protein interaction analysis mainly includes  protein-protein interaction, protein-metabolite interaction, protein-DNA interaction, and protein-RNA interaction.

Fig 1. Schematic of protein interactions

Fig 1. Schematic of protein interactions

Protein-Protein Interaction

Protein-protein interaction (PPI) is a binding process between two or more proteins, and it is universal in all life activities. In fact, PPI is at the center of various interactions in all living cells. It is seen in biochemistry, metabolism, genetics, molecular biology and other research fields. And the current main technical methods to research PPI include yeast two-hybridization, co-IP, fluorescence colocalization, GST-pull down, and BiFC, etc. By researching PPIs, people can gain a deeper understanding of disease development and open up new ideas for developing new therapies.

Protein-Metabolite Interaction

In life activities, proteins play a cellular regulatory role by interacting with some small molecule metabolites. It is supposed that there are millions of protein-metabolite interactions (PMIs), which are no less complex than PPI networks. Therefore, research into PMI is very essential for both protein and metabolite studies.

Protein-DNA Interaction

Interactions between DNA and proteins are associated with many cellular life activities, such as DNA replication and transcription, and virus infection and proliferation. With technology development, there are many methods for studying protein-DNA interactions, e.g., gel blocking, DNase I footprinting experiments, ChIP-Seq, etc. Accurately analyzing protein-DNA interactions can reveal their recognition and development, which is essential for a deeper understanding of gene regulation in physiological or pathological environments.

Protein-RNA Interaction

Protein-RNA interactions play a key role in biological processes. It affects many functions of many proteins and RNAs, and it cannot be ignored in biological research. For example, RNA can be a target for proteins and applied to drug development or treatment, meanwhile, protein can also be a target drug for regular RNA transcription. There are methods for studying protein-RNA interactions, e.g., RNA pull-down, CHIRP and RIP, etc. The study of protein-RNA interactions contributes to a better description of biological processes and provides new ideas and methods for biomedical research.

Protein interaction is essential for the study of cellular processes, disease pathways, drug discovery and targeted therapy development. With the knowledge accumulated and technology advanced, it has become easier to study interactions between proteins, nucleic acids, metabolites, etc., and this advances biotechnology and medicine.

Our Service

With years of experience, Creative Proteomics offers a wide range of high quality protein interaction analysis services. According to your research requirements, you can choose any of the following services.

Creative Proteomics provides comprehensive and high-quality proteomics analysis services. With highly specialized technical capabilities and professionals, we are committed to assisting clients around the world in the fast-growing field of proteomics with fast turnaround and high-quality data at competitive prices. Our clients can contact our staff directly and get prompt responses to their inquiries. If you are interested in our services, please contact us for more details.

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