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Palmitoylation Analysis Service

Palmitoylation, a distinctive reversible lipid modification, wields control over protein association with cell membranes and transport across membranes. At Creative Proteomics, our expertise extends to high-quality palmitoylation analysis services. We specialize in the identification, quantification, and characterization of palmitoylation, ensuring valuable insights for your protein research initiatives.

What is Palmitoylation

Protein palmitoylation stands as a crucial post-translational modification, involving the addition of a palmitoyl group—derived from palmitic acid—to specific cysteine residues of proteins. This modification is dynamic and reversible, exerting profound effects on protein localization, stability, and function within the cell. Palmitoylation is orchestrated by palmitoyl acyltransferases (PATs) and has emerged as a pivotal regulator of diverse cellular processes.

Fig.1 Schematic of palmitoylation

Fig.1 Schematic of palmitoylation (Li, X. et al.; 2022)

Palmitoylation introduces a 16-carbon saturated fatty acid (palmitate) to the target protein, facilitating its association with cellular membranes. This reversible modification dynamically regulates the subcellular localization of proteins, impacting their trafficking and membrane interactions. The attachment of palmitate to cysteine residues is often termed S-palmitoylation, and it can occur alone or in combination with other lipid modifications, such as myristoylation or prenylation. The reversible nature of palmitoylation provides a nuanced mechanism for cellular control, allowing proteins to shuttle between membrane and non-membrane compartments in response to cellular signals.

Applications of Palmitoylation Analysis

Our Service

Creative Proteomics has advanced protein detection technologies and can provide customized services to researchers and scientists to help them reveal the complexity of PTM using powerful mass spectrometry technologies. Our services are thoughtful and detailed and the process of palmitoylation analysis service is as follows:

Fig.2 Palmitoylation analysis workflow

Fig.2 Palmitoylation analysis workflow

Creative Proteomics brings a wealth of experience to the field of protein research. Our comprehensive services and products cover the entire spectrum of utilizing suitable and efficient gateways. Utilizing our proprietary platform, we have successfully implemented many proteomics research projects. If you are interested, please contact us for more information and a quote.

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