Antibody Identification Analysis Service

Monoclonal antibodies (mAbs) are being developed for a wide range of indications from cancer to infectious diseases to high cholesterol. Antibody-drug conjugate (ADC) is a monoclonal antibody linked to a biologically active drug through a chemical linker. Creative Proteomics can provide various solutions for the identification of these antibody drugs.

The antibody drug identification and analysis platform is dedicated to the development of complete solutions for in vitro functional identification, physical and chemical characterization, and combined characterization to support the screening, evaluation, analysis, or quality control needs of biological drugs at all stages of discovery through development.

Reference materials and detection methods are two important technical support points for antibody drug quality control. Standard materials with stable and uniform properties are an essential and important factor in the establishment of methodology. Creative Proteomics has established a professional analysis platform. We will customize the exclusive solution for you in accordance with relevant regulations, such as ICH guidelines, and your special requirements.

Antibody Identification Analysis Service We Can Provide:

Instrument Platform of Antibody Identification Service:

Creative Proteomics utilizes high-resolution mass spectrometry, liquid phase mass spectrometry, and capillary electrophoresis techniques to effectively and accurately identify and analyze the physical and chemical properties of vaccine proteins.

1) Mass spectrometry

The ultra-high resolution MS instrument has excellent resolution, sensitivity, dynamic range and quality accuracy, and can analyze antibody proteins more quickly and accurately.

• The relative molecular mass determination by mass spectrometry mainly uses electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) plasma sources. After protein ionization, the mass-to-charge ratio is measured by a mass analyzer to calculate the relative molecular mass, and compared with the theoretical relative molecular mass to initially verify whether the antibody structure is normal.
• To identify the primary structure of antibody drugs, you can choose liquid-mass peptide map or peptide mass fingerprint analysis. This method determines the sequence of each peptide by comprehensive analysis of the relative molecular mass measurement results of mass spectrometry and the protease hydrolysis characteristics.

2) High performance liquid chromatography

HPLC can effectively analyze the heterogeneity of antibody drugs and recombinant protein drugs. For example, size exclusion chromatography (SEC) takes advantage of the difference in molecular spatial structure, and can effectively analyze samples such as antibody multimers, fragments, and PEGylated proteins.

Advantages of Antibody Identification Service:

• Short time-consuming: Mature technology and advanced equipment accelerate the progress of the project.
• Advanced technology platform: Equipped with high-resolution mass spectrometry, liquid mass spectrometry and other equipment.
• Rapid turnaround time: 5-7 days can provide customers with accurate and comprehensive experimental reports.
• Customized service: We can provide you with tailor-made services based on your needs, and you can also choose your own analysis solutions.

Creative Proteomics will strictly comply with relevant regulations and ICH guidelines to provide you with a comprehensive antibody identification and analysis solution. We have mature analytical methods and are confident to provide professional technical support for biopharmaceutical companies in the R&D or production process. Looking forward to working with you. If you have other questions, please feel free to contact us.