Applications of Proteomics in Virus Research
Emerging infectious diseases (EIDs) pose a serious threat to public health worldwide, especially those induced by viruses. In order to better understand pathogenic mechanisms of viruses, identify new biomarkers for diagnosis, and facilitate early detection of viral disease, proteomics has been applied. Creative Proteomics is a forward-looking research institute as well as a leading custom service provider in the field of viral proteomics. Here, we focus on the proteomic study of a range of viruses in recent years, including human immunodeficiency virus (HIV), Zika virus (ZIKV), Crimean-Congo hemorrhagic fever virus (CCHFV), herpes simplex virus 1 (HSV-1), dengue virus (DENV), severe acute respiratory syndrome coronavirus (SARS-CoV), and influenza virus.
Proteomics: a powerful tool for studying virus infection
Over the past two decades, proteomics as a promising experimental tool for global profiling has made significant technological advances. Proteomics can offer fast and reliable data based on improved methods and advanced instruments, such as polyacrylamide gel separations, micro-and nano-flow LC fractionations. The tremendous improvements in the analytical capabilities of mass spectrometry have enabled protein identification at the atomic level. Furthermore, the progress of the field is accompanied by the development of sample preparation strategies, bioinformatics tools, and database search algorithms. As a result, proteomics can greatly facilitate researchers to tackle complex and dynamic processes, including viral infections.
So far, proteomic approaches have been applied to investigate many aspects of viruses, such as,
- The analysis of viral particles (determination of all proteins that compose the infectious virus)
- Viral-induced proteome alterations in time and space
- Viral-pathogen protein-protein interactions (PPI)
- Viral-induced regulation of protein posttranslational modifications (PTMs)
Fig1. Overview of proteomic tools that have been utilized in the study of host-pathogen interactions. (Jean Beltran, P. M., et al, 2017)
Application of proteomics in virus research
Creative Proteomics is an international contract research organization (CRO) providing viral proteomic, metabolomic and other analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Here we explore the recent proteomics in studying virus research. We will focus on the proteomic methods that have been employed to study viral disease progression and the final results obtained.
Proteomics is able to provide rapid and large-scale viral protein characterization, significantly contributing to understanding host-viral protein interactions, finding biomarkers to monitor the infection course, and exploring the mechanisms of viral pathogenesis. Therefore, proteomics is an indispensable tool in virus research and its role will be expanded further in the future. Creative Proteomics is dedicated to providing a series of proteomic techniques to help customers quickly and comprehensively investigate viral proteomics. Our services include three major parts, including viral protein structure detection, global proteome profiling, mass spectrometry-based viral proteomics. We are committed to providing you with the best strategy according to the specific project needs of our global clients.
For more information on how we can help you, please feel free to contact us or directly send us an inquiry.
References
- Jean Beltran, P. M., et al. (2017). "Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases." Molecular systems biology, 13(3), 922.
- Lum, K. K., & Cristea, I. M. (2016). "Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection." Expert review of proteomics, 13(3), 325-340.
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