Viral MS-Based Metabolomics Service
Over the past two decades, the study of metabolomics driven by a wide range of applications has been growing exponentially. There are two major analytical avenues for the analysis of metabolic species in the field of metabolomics, including nuclear magnetic resonance (NMR) and mass spectrometry (MS). Due to its inherent high sensitivity as well as fast data acquisition, MS-based methods are playing the dominant role in the metabolomics field. Creative Proteomics is an international contract research organization (CRO) providing advanced viral metagenomic sequencing, proteomics, metabolomics, glycoproteomics analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Based on state-of-the-art equipment and wide-ranging expertise in biotechnological applications, we are proud to offer a range of MS-based metabolomics methods to advance virus research.
Service offering in Creative Proteomics
MS-based metabolomics analyses can be exploited to understand the host-virus interactions and screen host samples for biomarkers that feature specific states, which will further facilitate disease diagnosis, prognosis, and staging, as well as the development of new drugs with applications in viral infections. We offer a range of MS-based metabolomics technologies to facilitate viral metabolomics research. We provide the following services, but are not limited to them.
Gas chromatography-mass spectrometry (GC-MS)—suitable for the determination of volatile metabolites
GC-MS is ideal for volatile metabolites analysis, which has the advantages of high sensitivity, high resolution, and fragmentation repeatability. We have developed an automated high-throughput GC-MS platform with sample derivatization and quantitative method. Therefore, we are able to simultaneously measure dozens of metabolites within minutes, including some nonvolatile constituents.
Liquid chromatography-mass spectrometry (LC-MS)—provides the wide coverage of detectable metabolites
LC-MS has become the dominating analytical technique in the field of global metabolite profiling. As compared to GC-MS, the mobile phase changes from gas to liquid. Therefore, the technique has a higher tolerance to volatility and a wider metabolite coverage. We offer LC-MS, including reverse-phase LC for molecules with higher hydrophobicity and hydrophilic interaction chromatography (HILIC) for polar metabolites.
Capillary electrophoresis-mass spectrometry (CE-MS)—provides medium coverage of the metabolome and is suitable for the detection of charged metabolites
CE-MS is a robust technique for polar and charged metabolite metabolites, which provides medium coverage of the metabolome. Although the system stability of CE-MS is less stable than LC-MS, GC-MS, we can offer metabolite analyses using CE-MS, especially for precious samples.
Matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)—has rapid sample analysis ability
MALDI-MS is an indispensable analytical tool for complex sample analyses. The technique is characterized by rapid analysis ability, relatively high tolerance towards salts, and low sample consumption. Based on the advanced MALDI-MS platform, we can not only analyze macromolecule metabolites including nucleic acids, peptides, and proteins but also detect small molecule metabolites in the low mass region based on various novel matrices.
Advances based on MS are an important driving force for the development of metabolomics. Creative Proteomics is committed to providing high-quality service to greatly accelerate our customers' project progress and success. For more information on how we can help you, please feel free to contact us.
* For research use only.
