Applications of Viral Glycoproteomics
Glycosylation is a complex biological process, and the functional study of glycosylation, as well as the relationship between glycosylation of virus and host proteins, has just started. However, with the development of technology, the study on glycosylation will be further advanced.
Status and function of glycosylation of viral envelope proteins
Glycosylation plays an important role in the life cycle of viruses, involving stability, antigenicity and infectivity. The functions of common envelope viral glycoproteins are shown in the table below.
(Li, Y., et al, 2021)
Application of glycosylation function of viral glycoproteins
Starting from the study of glycoproteomics, mass spectrometry (MS) and bioinformatics methods are used to reveal the glycosylation modification process between virus and host cells, which can be used for the study of the interaction mechanism between virus and host cells, and open up a new field of vision. Furthermore, glycosylated modified glycoproteins provide new tools for the diagnosis and treatment of viral diseases. The specific applications include,
Elucidating the mechanism of protein glycosylation modification during viral infection is helpful to explore novel molecular targets of glycosylation modification related to important pathogen infection and immune evasion, and to create new anti-infection strategies targeting abnormal glycosylation modification, which is also a new way to develop vaccines.
Considering the important role of interactions between glycosides and lectins in the process of many viral infections, the use of these interacting molecules as drug targets in the process of antiviral therapy has attracted much attention, and has been proved by many related studies and used in antiviral research.
- The development of glycoprotein related technology
With the development of glycoprotein analysis and identification techniques, studies on the structure of glycoprotein and glycan are making continuous progress. There are several common techniques used for glycoprotein analysis, such as mass-spectrometric technique and carbohydrate microarray.
- For the diagnosis and treatment of viral diseases
The degree of glycosylation modification of protein can reflect the physiological or pathological state of the body, and some glycoproteins can participate in the occurrence and development of diseases. Glycosylation modifications can be involved in the progression of viral diseases, and plays an increasingly important role in the diagnosis and treatment of viral diseases.
Here, we underscore the importance of glycosylation of viral glycoproteins. High throughput analysis of glycosylation on viral and host proteins, data compilation as well as data sharing greatly promote the application of glycosylation functions. Creative Proteomics is an contract research organization (CRO) providing a series of viral glycoproteomics services. We are dedicated to providing state-of-the-art equipment and wide-ranging expertise in biotechnological applications to academic and industry clients.
Our array of services can be tailored to meet your needs, including,
Feel free to contact us with your inquiries about viral glycoproteomics.
Reference
- Li, Y., et al. (2021). “The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection.” Frontiers in Immunology, 12, 1544.
* For research use only.
