Integrated Transcriptomics, Proteomics and Metabolomics Analyses
Multi-omics combined analysis can systematically and comprehensively analyze the function and regulation mechanism of biomolecules in the process of viral infection, and provide a basis for further virus research and related applications. As a good partner of pharmaceutical companies and research institutions, Creative Proteomics is able to provide transcriptome, proteomics and metabolomics experiments and multi-omics joint analysis services. Thanks to our long-term experience, high degree of expertise in virus research, and the application of modern technologies, we can provide high-quality and customized service to greatly accelerate our customers' project progress and success.
Fig1. Integrated transcriptomics, proteomics and metabolomics analyses for virus research (Top-down and bottom-up data reduction integration approaches).
To better understand the physiopathology of viral infection and to identify the molecules involved in the mechanisms of host resistance/susceptibility, accurate and more complete identification of cellular and viral genes is necessary. Through bioinformatics analysis of differentially expressed genes, pathways and genes involved in viral infection can be revealed to a certain extent. Further verification and screening of candidate genes related to viral infection can be conducive to understanding the pathogenic mechanism of virus and the subsequent research and development of antiviral drugs.
Proteomics is used to analyze all proteins in body, tissue, cell or subcellular components under normal and pathological conditions, and to compare the whole proteome with dynamic changes in different space and time. By analyzing the differences in expression quantity, expression level and modification state among different proteomes, we can find the specific proteins related to viral infection. Therefore, proteomics plays an important role in the study of the interaction between virus and host, and the development of related antiviral target drugs and lead compounds.
Since the small-molecular intermediates and products of metabolism can reflect unique chemical patterns generated by specific cellular processes, metabolites as indicators of specific disease states or stages have been applied to investigate and diagnose the progression of viral infections. Metabolomics analysis has several major advantages in virological research, including contributing to understanding host-virus interactions, providing prognostic data, assisting in evaluating the efficacy of therapeutic intervention, and so on.
Integrated transcriptomics, proteomics and metabolomics analyses in Creative Proteomics
Multi-omics analysis based on "holistic" view can help researchers to predict biomarkers and potential drug therapeutic targets and provide theoretical basis and support for the analysis of viral pathogenesis. Based on state-of-the-art technology and software applications, we provide one-stop services, ranging from experimental design, sample detection to customized bioinformatics analysis to meet a variety of project needs. Specifically, our services can meet customer needs from technical selection and experimental design, the overall presentation of multi-omics data, classification and integrated analysis of multi-omics data, and further mining and display of multi-omics data.
Fig2. Discovery pipeline for novel modulators of virus-host interactions.
Application of our service
- Study the mechanism of virus invasion
- Study the virus-host interaction
- Discovery of lead compounds
- Evaluate the efficacy of viral drug therapy
- Screening of drug targets and potential biomarkers
- Vaccine development
Benefits of our services
- Professional team of scientists and advanced instruments
- Rich experience in design and analysis of multi-omics analysis
- Highly customized service to satisfy customers
- Strictly keep confidential the client's project information and experimental data
Multi-omics analysis based on multi-platform provides a new idea for disease basic science and precision medicine research. Creative Proteomics' success lies in constantly optimizing our services. Whatever the scale and complexity of your project for a professional, please feel free to contact us for reliable and highly customized solutions.
* For research use only.
