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Applications

Multiple Applications of Post-Translational Modification (PTM) Analysis

The formation of PTM is a key source of protein complexity and diversity. These modifications regulate protein structure, activity, function, and cellular location, involved in a variety of normal cellular functions and disease pathogenesis.

Protein Post-Translational Modifications in Biological Research

PTMs take part in various cellular processes, such as signal transduction, protein-protein interactions, cellular metabolism, protein trafficking, protein stability and localization, DNA repair, and more.

Protein Post-Translational Modifications in Disease Research

Disruption of PTMs can lead to the dysfunction of important biological processes, which can result in a variety of diseases. Thus, the footprints of PTM dysregulation can be seen in many diseases.

Protein Post-Translational Modifications in Drug Discovery and Development

In addition to promoting biomarker discovery in a variety of disease conditions, research on PTMs has also facilitated the discovery and development of targeted drugs.

Protein Post-Translational Modifications in Microbes (Bacteria and Viruses)

In addition to eukaryotes, PTMs are widely found in microbiota, including bacteria and viruses. As one of the important strategies of microbiota for environmental adaptation, protein PTMs control a number of fundamental features of microbial biology by regulating protein complexity.

Protein Post-Translational Modifications in Plants

Protein PTMs play key roles in almost all plant biological processes, including plant signal transduction, metabolism, plant immunity and disease resistance, cell differentiation, and other cellular events.