In the study of acetylation modification of proteins, in addition to determining the presence of acetylation of target proteins and performing the identification and quantification of acetylation, it is essential and important to resolve the effects of acetylation on target proteins as well as to explore the biological functions of acetylation of target proteins. Creative Proteomics also specializes in providing bioinformatic acetylomics data analysis services. Our professional experts have established robust and effective bioinformatics workflows for the analysis of lysine acetylation. We are committed to providing a variety of bioinformatics analysis and custom services to meet the diverse needs of our clients.
The biological significance of protein acetylation
Protein acetylation is the process of adding acetyl groups to the lysine residues of proteins by the action of acetyltransferases, a mechanism by which cells control gene expression, protein activity, or physiological processes. The function of acetylation is mainly focused on the effect on cellular chromosome structure and the activation of transcriptional regulators in the nucleus. In recent years, it has been found that a large number of non-nuclear proteins are modified by acetylation under physiological conditions, with a wide range of biological significance.
- Acetylation is commonly found in human metabolic enzymes and has the ability to regulate metabolic pathways and the activity of metabolic enzymes.
- Acetylation is widespread from lower prokaryotic cells to higher mammals, including humans, and their regulation of metabolism is extremely conserved during the evolution of life.
- Acetylation events have high functional specificity and are closely related to diseases such as tumors.
Acetylomics data analysis service
We have years of experience in large-scale proteomics research and post-translational modification (PTM) proteomics analysis. We have established an industry-leading platform for PTM proteomics analysis based on advanced bioinformatics analysis methods. The MS data is processed using an effective and systematic lysine acetylomics bioinformatics workflow developed at our platform. Our bioinformatics analysis contents include:
- Characteristic distribution of identification results
-Peptide length.
-Protein coverage distribution.
-Unique peptide distribution. - Acetylation sites identification
- Quantitative acetylated protein analysis
-Protein abundance value distribution.
-Protein abundance ratio distribution between samples.
-PCA analysis.
-Statistical analysis of significant differences. - Acetylation site motif prediction.
- Functional annotation of acetylated proteins
-Acetylated protein GO Annotation.
-Acetylated protein KOG Annotation.
-Acetylated protein pathway annotation. - Protein network interactions prediction
- Protein domain prediction
Major benefits of our service
- Advanced bioinformatics analysis methods and tools.
- A research team with extensive experience in PTM analysis.
- Providing a variety of bioinformatics analyses.
- Providing customized bioinformatics solutions for each contract research project.
Workflow of our service
Creative Proteomics serves as a global leader in PTM proteomics analysis. We are driven by customer needs, a solid scientific basis, and innovative technologies to advance and develop scientific research. If you are interested in our protein acetylation identification service, please feel free to contact us for information.
Our products and services are for research use only.
