Protein phosphorylation is involved in regulating a variety of protein functions, such as protein catalytic activity and stability, subcellular localization, and the regulation of dynamics of protein-protein interactions (PPI). As a reversible and common post-translational modification (PTM) as well as an important molecular switch protein, phosphorylation is intricately controlled by kinases and phosphatases. Since phosphorylation is associated with cellular processes ranging from cell cycle progression and cell differentiation to apoptosis, dysfunctional phosphorylation can severely disrupt intracellular homeostasis and lead to various diseases and cancers. Creative Proteomics has many years of experience in the field of bioinformatics analysis, especially in the bioinformatics analysis of protein PTMs. We are proud to provide phosphoproteomics data analysis service and are committed to providing customized and highest quality services to our clients worldwide.
Bioinformatics analysis of phosphoproteomics datasets
With the deepening of proteomics and systems biology research, the scale of data output is getting bigger, and the interface between various types of data is getting more and more complex, while the requirements for researchers to interpret the biological functions of samples are getting higher. Nowadays, bioinformatics analysis has become an indispensable and important part of the proteomics research process. Protein phosphorylation modifies protein substrates at specific amino acid residues to regulate protein function, and protein-protein interactions, therefore, have a broad impact on cellular signaling. Knowledge of interacting proteins and signaling networks has provided researchers with a fundamental understanding of the molecular mechanisms of cell and tissue function and has also contributed to the development of drugs, new drug targets, and combination therapeutic strategies.
Phosphoproteomics data analysis service at Creative Proteomics
Based on a powerful and novel bioinformatics platform, we are able to help our clients achieve efficient and rapid analysis of phosphoproteomics data, providing the basis and clues for analyzing the molecular mechanisms of cell and tissue function and disease. Our bioinformatics platforms and methods reduce the variability of analysis processes, enabling the reproducibility of the analysis pipelines. Specifically, our services include the following, but are not limited to:
Standard bioinformatics analysis
- MS data quality control
- Protein phosphorylation identification
-Phosphorylated protein identification.
-Phosphorylation site identification.
-Quality assessment of identification results. - Protein phosphorylation quantification
-Differential analysis.
-Principal component analysis (PCA).
-Cluster analysis.
-Time series analysis. - Functional annotation of phosphorylated proteins
-Phosphorylated protein GO Annotation.
-Phosphorylated protein KOG Annotation.
-Phosphorylated protein pathway annotation. - Motif analysis of phosphorylated peptides
Advanced bioinformatics analysis
- Phosphorylated protein network interaction analysis.
- Phosphorylated protein domain analysis
- Phosphorylated protein subcellular localization
Customized bioinformatics analysis
-Customized bioinformatics analysis services can be negotiated according to customer needs.
Advantages of our bioinformatics platform
- Provide a variety of options for data management and analysis.
- Systematic bioinformatics analysis process traceability.
- Bioinformatics analysis for multiple types of data, mainly mass spectrometry (MS) data.
- Bioinformatics analysis in a transparent and scalable way.
Creative Proteomics serves as a global leader in PTM proteomics analysis. We are driven by customer needs, a solid scientific basis, and innovative technologies to advance and develop scientific research. Please contact us with any questions to get your research started.
Our products and services are for research use only.
