Protein ubiquitination is an evolutionarily conserved post-translational modification (PTM) that can degrade substrates and control a variety of cellular functions. The extensive cellular functions of the ubiquitinated network offer great promise for the detection of potential targets and the identification of the respective receptors. In addition to ubiquitination identification and quantitation, Creative Proteomics also offers systematic and custom bioinformatics analysis for researchers and professionals, such as protein annotation, functional classification, functional enrichment, and cluster analysis based on functional enrichment proteins. We are dedicated to helping researchers and professionals study the ubiquitination landscape of a variety of complex samples, facilitate the search and identification of novel molecular biomarkers, and provide valuable information for the diagnosis and discovery of new therapeutic anti-cancer strategies.
Bioinformatics analysis of ubiquitylomics datasets
Protein ubiquitination not only participates in protein degradation but also directly affects protein activity and localization. Ubiquitination can regulate multiple cellular processes, such as cell cycle progression, cell apoptosis, transcriptional regulation, DNA damage repair, and so on. In recent years, more and more datasets about ubiquitylomics are published. Therefore, it is necessary to organize and analyze these data efficiently. There are several major parts of ubiquitylomics data bioinformatics analysis, including identification and quantitation of ubiquitination, analysis of ubiquitination motif, functional annotation of ubiquitinated proteins, and construction and analysis of ubiquitination networks.
Ubiquitylomics data analysis service
We have years of experience in large-scale proteomics research and PTM proteomics analysis. Based on the research progress of bioinformatics analysis methods, we have established the industry-leading PTM proteomics analysis platform. We are able to analyze mass spectrometry data from ubiquitination studies with an effective and systematic bioinformatics workflow. Specifically, our bioinformatics analysis service consists of the following components:
- Characteristic distribution of identification results
-Peptide length.
-Protein coverage distribution.
-Unique peptide distribution. - Ubiquitination sites identification
- Quantitative ubiquitinated protein analysis
-Protein abundance value distribution.
-Protein abundance ratio distribution between samples. - Differential ubiquitinated protein expression analysis
-Subcellular location of differentially ubiquitinated proteins.
-Functional classification of differentially ubiquitinated proteins.
-Functional enrichment analysis of differentially ubiquitinated proteins.
-Cluster analysis of differentially ubiquitinated proteins.
-Protein-protein interaction (PPI) network of differential ubiquitinated proteins. - Motif analysis of ubiquitination
- Functional annotation of ubiquitinated proteins
-Ubiquitinated protein GO annotation.
-Ubiquitinated protein COG annotation.
-Ubiquitinated protein pathway annotation. - Protein network interactions prediction
- Protein domain prediction
- Custom analysis
Advantages of our bioinformatics platform
- Providing a variety of options for data management and analysis.
- Systematic bioinformatics analysis process traceability.
- Bioinformatics analysis for multiple types of data, mainly MS data.
- Bioinformatics analysis in a transparent and scalable way.
Creative Proteomics specializes in applying optimized modified peptide enrichment techniques, advanced MS technologies, and novel bioinformatics analysis tools for protein PTM analysis. If you have any other questions about our services or need further assistance, please contact us. We are always ready to help you!
Our products and services are for research use only.
