Functional Overview of PTMs
PTMs have been shown to have a range of cellular
functions, and each modification has multiple effects on protein structure and function
involving protein signaling, activity, stability, metabolism, and localization. PTMs also play
key roles in a wide range of biological regulatory mechanisms, such as signaling pathways,
protein-protein interactions, DNA damage response, and metabolic pathways. Therefore, the
dysregulation in PTMs can lead to a variety of diseases, including diabetes, cardiovascular
disease, neurological disorders, and different cancers.